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Fc fragment of IgE, low affinity II, receptor for (CD23)
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| PDB rendering based on 1t8c. | |||||||||||
| Available structures: 1t8c, 1t8d, 2h2r, 2h2t | |||||||||||
| Identifiers | |||||||||||
| Symbols | FCER2; CD23; CD23A; CLEC4J; FCE2; IGEBF | ||||||||||
| External IDs | OMIM: 151445 MGI: 95497 HomoloGene: 1517 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 2208 | 14128 | |||||||||
| Ensembl | ENSG00000104921 | ENSMUSG00000005540 | |||||||||
| Uniprot | P06734 | P20693 | |||||||||
| Refseq | NM_002002 (mRNA) NP_001993 (protein) |
NM_013517 (mRNA) NP_038545 (protein) |
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| Location | Chr 19: 7.66 - 7.67 Mb | Chr 8: 3.68 - 3.69 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
CD23, also known as Fc epsilon RII, or FcεRII, is the "low affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells and platelets.
There are two forms of CD23: CD23a and CD23b. CD23a is unconditionally present on B cells, while CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils and macrophages.[1]
The allergen responsible in dust mite allergy, Der-p-1, is known to cleave CD23 from a cells surface. As CD23 is soluble it can move freely and interact with cells in plasma. Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen specific B-cells, therefore increasing the production of allergen specific IgE. IgE in turn is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high affinity IgE receptor).
References
- ^ Abbas, A.K. and Andrew Licktman, 2003, Cellular and Molecular Immunology, pp.324-325. ISBN 0-7216-0008-5.
Further reading
- Kijimoto-Ochiai S (2002). "CD23 (the low-affinity IgE receptor) as a C-type lectin: a multidomain and multifunctional molecule". Cell. Mol. Life Sci. 59 (4): 648–64. PMID 12022472.
- Schwarzmeier JD, Hubmann R, Düchler M, et al. (2005). "Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia". Leuk. Lymphoma 46 (2): 157–65. doi:. PMID 15621797.
- Maekawa N, Kawabe T, Sugie K, et al. (1992). "Induction of Fc epsilon RII/CD23 on PHA-activated human peripheral blood T lymphocytes and the association of Fyn tyrosine kinase with Fc epsilon RII/CD23". Res. Immunol. 143 (4): 422–5. PMID 1387715.
- Rose K, Turcatti G, Graber P, et al. (1992). "Partial characterization of natural and recombinant human soluble CD23". Biochem. J. 286 ( Pt 3): 819–24. PMID 1417742.
- Maekawa N, Kawabe T, Sugie K, et al. (1992). "Induction of Fc epsilon RII/CD23 on PHA-activated human peripheral blood T lymphocytes and association of fyn tyrosine kinase with Fc epsilon RII/CD23". International journal of tissue reactions 14 (3): 121–30. PMID 1446976.
- Sugie K, Kawakami T, Maeda Y, et al. (1991). "Fyn tyrosine kinase associated with Fc epsilon RII/CD23: possible multiple roles in lymphocyte activation". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9132–5. PMID 1717997.
- Bettler B, Hofstetter H, Rao M, et al. (1989). "Molecular structure and expression of the murine lymphocyte low-affinity receptor for IgE (Fc epsilon RII)". Proc. Natl. Acad. Sci. U.S.A. 86 (19): 7566–70. PMID 2529542.
- Kikutani H, Inui S, Sato R, et al. (1987). "Molecular structure of human lymphocyte receptor for immunoglobulin E". Cell 47 (5): 657–65. PMID 2877743.
- Ikuta K, Takami M, Kim CW, et al. (1987). "Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins". Proc. Natl. Acad. Sci. U.S.A. 84 (3): 819–23. PMID 2949326.
- Yokota A, Kikutani H, Tanaka T, et al. (1988). "Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression". Cell 55 (4): 611–8. PMID 2972386.
- Lüdin C, Hofstetter H, Sarfati M, et al. (1987). "Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor". EMBO J. 6 (1): 109–14. PMID 3034567.
- Aubry JP, Pochon S, Gauchat JF, et al. (1994). "CD23 interacts with a new functional extracytoplasmic domain involving N-linked oligosaccharides on CD21". J. Immunol. 152 (12): 5806–13. PMID 7515913.
- Lecoanet-Henchoz S, Gauchat JF, Aubry JP, et al. (1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18". Immunity 3 (1): 119–25. PMID 7621072.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. PMID 8125298.
- Padlan EA, Helm BA (1994). "Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23)". Receptor 3 (4): 325–41. PMID 8142907.
- Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics 15 (1): 133–45. PMID 8432525.
- Chirmule N, Kalyanaraman VS, Lederman S, et al. (1993). "HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6". J. Immunol. 150 (6): 2478–86. PMID 8450224.
- Förster HH, Wäsch R, Kretschmar T, et al. (1996). "Genetic markers on chromosome 19p and prenatal diagnosis of HLA class II-deficient combined immunodeficiency". Pediatr. Res. 38 (5): 812–6. PMID 8552454.
- Bajorath J, Aruffo A (1996). "Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models". Protein Sci. 5 (2): 240–7. PMID 8745401.
- Frémeaux-Bacchi V, Bernard I, Maillet F, et al. (1996). "Human lymphocytes shed a soluble form of CD21 (the C3dg/Epstein-Barr virus receptor, CR2) that binds iC3b and CD23". Eur. J. Immunol. 26 (7): 1497–503. PMID 8766552.
See also
- Cluster of differentiation, a list of all the CD-numbered proteins
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